With the proliferation of information technology devices comes a massive increase in the number of information systems that are developed to meet the demands of users. By default, designers and developers of information systems tend to design for users without disabilities. The consequences for people with disabilities are enormous. This chapter aims to propose a disability-aware approach to information systems design that advocates that stakeholders consider the needs of people with disabilities throughout development. This aim is achieved by reviewing some of the difficulties encountered by people with disabilities when interacting with information systems, proposing a disability-aware approach and examining how this could be practically implemented through e-learning design. The recommendations from 48 students with disabilities from two universities in the United Kingdom and Canada are presented. The chapter also looks at possible future research for those interested in pursuing such approach.